Sometimes bad outlook profiles and stupid mail rules can cause rapid mailbox growth and transaction log growth for particular individuals. Trouble Shooting this can be a real pain, however this article I found by Mike Lagase is fantastic and goes into a great deal of detail. I highly recommend reading it.
http://blogs.technet.com/mikelag/archive/2009/07/12/troubleshooting-store-log-database-growth-issues.aspx
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